Standardized protocol: prospective longitudinal cohort study of newborns born to mothers with and without Oropouche virus infection to assess the risk of adverse pregnancy outcomes - Preliminary version (available in Spanish)

The Pan American Health Organization (PAHO)/World Health Organization (WHO) has adapted standardized clinical and epidemiological investigation protocols and questionnaires aimed at addressing key public health issues related to Oropouche virus (OROV).

As of July 16, 2024, 7,688 confirmed cases of Oropouche have been reported in five countries in the Region of the Americas: the Plurinational State of Bolivia (n= 313), Brazil (n= 6,976), Colombia (n= 38), Cuba (n= 74), and Peru (n= 287). During the last quarter, cases of Oropouche have been reported in areas and countries where no autochthonous cases had been previously reported.

This protocol is designed to systematically collect biological samples, epidemiological, clinical and exposure data and share them rapidly in a format that is easily aggregated, tabulated and analyzed in multiple different settings at the regional level. We encourage all research centers to contribute to this effort regardless of their resource availability or patient volume, keeping in mind that ownership of the primary data remains with each country or center.

*Document available in Spanish