The world is undergoing a profound demographic shift: there are now more persons older than 65 than children younger than 5. However, quality of life is not improving correspondingly. As we age, our immune system weakens (immunosenescence) and leaves the body exposed to diseases to which it had gained immunity earlier. Also, chronic diseases exacerbate health outcomes when coupled with infections later in life. There are multiple missed opportunities in the Americas for people to fully benefit from vaccines at all stages of life.
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