Differentiated and simplified pre-exposure prophylaxis for HIV prevention: update to WHO implementation guidance

WHO recommends multiple pre-exposure prophylaxis (PrEP) options as part of combination prevention approaches and there has been a global uptake of PrEP into national guidelines and widespread implementation of PrEP services, although projects and programmes are still commonly small-scale. In many countries, services have been demedicalized, simplified, differentiated, digitalized, and integrated to increase uptake and effective use of PrEP.