Acute, severe hepatitis of unknown origin in children. 17 May 2022

This technical note follows the previous reports regarding the event of acute, severe hepatitis of unknown origin in children disseminated by the Pan American Health Organization / World Health Organization (PAHO/WHO) on 23 April 2022 (two reports)1, 25 April 20222, 29 April 20223, and 10 May 20224.

As of 15 May 2022, a total of 429 probable cases have been reported from 22 countries, including 26 cases that have required liver transplantation. In the Region of the Americas to date, a total of 33 probable cases in 6 countries have been reported to PAHO/WHO.

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