Situation Report: Mpox Multi-Country Outbreak - Region of the Americas - 28 February 2025 2025

Between 2022 and 31 January 2025, a total of 123,273 confirmed cases of mpox have been reported globally, from 127 countries and territories. 

The Region of the Americas (54.9%) contributes the largest proportion of cases, followed by the European (23.4%) and African Regions (15.8%). 

In the Region of the Americas, a cumulative total of 67,746 confirmed cases of mpox, including 151 deaths were reported in 31 countries and territories between 2022 and 2025. 

In 2025, a total of five countries (Brazil, Canada, Chile, Mexico, and the United States) have reported mpox cases, with no recorded deaths. The United States of America reported its third and fourth clade Ib mpox cases—in New Hampshire on 30 January 2025, and New York State on 12 February 2025 respectively. Both cases have been confirmed to be imported infections in individuals with a history of travel to areas with ongoing mpox circulation.